Treating addiction is a complicated process involving addressing everything from social and psychological to biological issues — all of which play a part in keeping men sick. All of these variables are interdependent and can be linked to one very critical area of the brain called the prefrontal cortex. This part of the brain is responsible for mood regulation, interpersonal connections, impulse control, forward thinking, morality, empathy and other critical human qualities. When a person is using drugs, this part of the brain stops functioning properly. This kicks off the vicious cycle of self destruction that we commonly know as addiction.